Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes. Including Amyloid beta Sci Transl Med. 2012;4:147.
Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M. Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J Neurosci. 2013;33:18190–9.
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O’Donnell J, Christensen DJ, Nicholson C, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342:373–7.
Holstein-Ronsbo S, Gan YM, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, et al. Glymphatic influx and clearance are accelerated by neurovascular coupling. Nat Neurosci. 2023;26:1042.
Hladky SB, Barrand MA. The glymphatic hypothesis: the theory and the evidence. Fluids Barriers CNS. 2022;19:9.
Hussain R, Tithof J, Wang W, Cheetham-West A, Song W, Peng W, Sigurdsson B, Kim D, Sun Q, et al. Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema. Nature. 2023;623:992–1000.
Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17:1016–24.
Jessen NA, Munk ASF, Lundgaard I, Nedergaard M. The glymphatic system: a beginner’s guide. Neurochem Res. 2015;40:2583–99.
Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science. 2020;370:50.
Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang LJ, Singh I, Deane R, Nedergaard M. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014;34:16180–93.
Wang Y-J, Sun Y-R, Pei Y-H, Ma H-W, Mu Y-K, Qin L-H, Yan J-H. The lymphatic drainage systems in the brain: a novel target for ischemic stroke? NRR. 2023;18:485–91.
Simon M, Wang MX, Ismail O, Braun M, Schindler AG, Reemmer J, Wang ZY, Haveliwala MA, O’Boyle RP, et al. Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid beta plaque formation in mice. Alzheimers Res Ther. 2022;14:59.
Drieu A, Du SL, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong FH, Kim K, Blackburn S, et al. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. 2022;611:585.
Wang XW, Lou NH, Eberhardt A, Yang YJ, Kusk P, Xu QW, Forstera B, Peng SS, Shi M, et al. An ocular glymphatic clearance system removes beta-amyloid from the rodent eye. Sci Transl Med. 2020. https://doi.org/10.1126/scitranslmed.aaw3210.
Xu JQ, Liu QQ, Huang SY, Duan CY, Lu HB, Cao Y, Hu JZ. The lymphatic system: a therapeutic target for central nervous system disorders. NRR. 2023;18:1249–56.
Benveniste H, Lee H, Ding F, Sun Q, Al-Bizri E, Makaryus R, Probst S, Nedergaard M, Stein EA, et al. Anesthesia with dexmedetomidine and low-dose isoflurane increases solute transport via the glymphatic pathway in rat brain when compared with high-dose isoflurane. Anesthesiology. 2017;127:976–88.
Hablitz LM, Vinitsky HS, Sun Q, Staeger FF, Sigurdsson B, Mortensen KN, Lilius TO, Nedergaard M. Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia. Sci Adv. 2019. https://doi.org/10.1126/sciadv.aav5447.
Albayram MS, Smith G, Tufan F, Tuna IS, Bostanciklioglu M, Zile M, Albayram O. Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes. Nat Commun. 2022;13:203.
He XZ, Li X, Li ZH, Meng JC, Mao RT, Zhang XK, Zhang RT, Huang HL, Gui Q, et al. High-resolution 3D demonstration of regional heterogeneity in the glymphatic system. J Cerebr Blood Met. 2022;42:2017–31.
Bechet NB, Kylkilahti TM, Mattsson B, Petrasova M, Shanbhag NC, Lundgaard I. Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system. J Cerebr Blood Met. 2020;40:1975–86.
Keil SA, Braun M, O’Boyle R, Sevao M, Pedersen T, Agarwal S, Jansson D, Iliff JJ. Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain. Neurophotonics. 2022;9: 031935.
Ma Q, Ries M, Decker Y, Mueller A, Riner C, Buecker A, Fassbender K, Detmar M, Proulx ST. Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain. Acta Neuropatho. 2019;137:151–65.
Gu X, Song Q, Zhang Q, Huang M, Zheng M, Chen J, Wei D, Chen J, Wei X, et al. Clearance of two organic nanoparticles from the brain via the paravascular pathway. J Control Release. 2020;322:31–41.
Miyakoshi LM, Staeger FF, Li QL, Pan CC, Xie LL, Kang HY, Pavan C, Dang JLA, Sun Q, et al. The state of brain activity modulates cerebrospinal fluid transport. Prog Neurobiol. 2023;229: 102512.
Li C, Chen G, Zhang Y, Wu F, Wang Q. Advanced fluorescence imaging technology in the near-infrared-ii window for biomedical applications. J Am Chem Soc. 2020;142:14789–804.
Wang F, Wan H, Ma Z, Zhong Y, Sun Q, Tian Y, Qu L, Du H, Zhang M, et al. Light-sheet microscopy in the near-infrared II window. Nat Methods. 2019;16:545.
Tian R, Zeng Q, Zhu SJ, Lau J, Chandra S, Ertsey R, Hettie KS, Teraphongphom T, Hu ZB, et al. Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics. Sci Adv. 2019. https://doi.org/10.1126/sciadv.aaw0672.
Zhang M, Yue J, Cui R, Ma Z, Dai H. Bright quantum dots emitting at 1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging. Proc Natl Acad Sci. 2018;115:201806153.
Ma Z, Zhang M, Yue J, Alcazar C, Zhong Y, Doyle TC, Dai H, Huang NF. Near-infrared iib fluorescence imaging of vascular regeneration with dynamic tissue perfusion measurement and high spatial resolution. Adv Funct Mater. 2018. https://doi.org/10.1002/adfm.201803417.
Bai L, Hu Z, Han T, Wang Y, Xu J, Jiang G, Feng X, Sun B, Liu X, et al. Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging. Theranostics. 2022;12:4536–47.
Tian R, Feng X, Wei L, Dai DG, Ma Y, Pan HF, Ge SX, Bai L, Ke CM, et al. A genetic engineering strategy for editing near-infrared-II fluorophores. Nat Commun. 2022;13:2853.
Li H, Wang M, Huang B, Zhu SW, Zhou JJ, Chen DR, Cui R, Zhang MX, Sun ZJ. Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis. Nat Commun. 2021;12:7149.
Xu JJ, Du YJ, Han TY, Zhu NN, Zhu SJ. Protein@cyanine-based NIR-II lymphography enables the supersensitive visualization of lymphedema and tumor lymphatic metastasis. Adv Healthc Mater. 2023;12:2301051.
Bojarskaite L, Vallet A, Bjornstad DM, Gullestad Binder KM, Cunen C, Heuser K, Kuchta M, Mardal K-A, Enger R. Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport. Nat Commun. 2023;14:953.
Li B, Zhao M, Feng L, Dou C, Ding S, Zhou G, Lu L, Zhang H, Chen F, et al. Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging. Nat Commun. 2020;11:3102.
Wang S, Fan Y, Li D, Sun C, Lei Z, Lu L, Wang T, Zhang F. Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing. Nat Commun. 2019;10:1058.
Persson NDA, Uusalo P, Nedergaard M, Lohela TJ, Lilius TO. Could dexmedetomidine be repurposed as a glymphatic enhancer? Trends Pharmacol Sci. 2022;43:1030–40.
Lilius TO, Blomqvist K, Hauglund NL, Liu G, Staeger FF, Baerentzen S, Du T, Ahlstrom F, Backman JT, et al. Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs. J Control Release. 2019;304:29–38.
Gakuba C, Gaberel T, Goursaud S, Bourges J, Di Palma C, Quenault A, de Lizarrondo SM, Vivien D, Gauberti M. General anesthesia inhibits the activity of the “glymphatic system.” Theranostics. 2018;8:710–22.
Hablitz LM, Pla V, Giannetto M, Vinitsky HS, Staeger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M. Circadian control of brain glymphatic and lymphatic fluid flow. Nat Commun. 2020;11:4411.
Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Staeger FF, Bork PAR, et al. Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science. 2020;367:1211.
Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, et al. Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. Brain. 2022;145:787–97.
Ma Q, Decker Y, Mueller A, Ineichen BV, Proulx ST. Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels. J Exp Med. 2019;216:2492–502.
Ma Q, Ineichen BV, Detmar M, Proulx ST. Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice. Nat Commun. 2017;8:1434.
Proulx ST. Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics. Cell Mol Life Sci. 2021;78:2429–57.
Sun YY, Zhu HJ, Zhao RY, Zhou SY, Wang MQ, Yang Y, Guo ZN. Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2/HO-1 pathway in MCAO mice. Redox Biol. 2023;66: 102852.
Pla V, Bork P, Harnpramukkul A, Olveda G, Ladron-de-Guevara A, Giannetto MJ, Hussain R, Wang W, Kelley DH, et al. A real-time in vivo clearance assay for quantification of glymphatic efflux. Cell Rep. 2022;40: 111320.
Zhang B, Li W, Zhuo Y, Xiang H, Li W, Liu H, Xie L, Gao Q, Tan S. L-3-n-Butylphthalide effectively improves the glymphatic clearance and reduce amyloid-beta deposition in alzheimer’s transgenic mice. J Mol Neurosci. 2021;71:1266–74.
Li W, Chen D, Liu N, Luan Y, Zhu S, Wang H. Modulation of lymphatic transport in the central nervous system. Theranostics. 2022;12:1117–31.
Mestre H, Mori Y, Nedergaard M. The brain’s glymphatic system: current controversies. Trends Neurosci. 2020;43:458–66.
Mestre H, Hablitz LM, Xavier ALR, Feng WX, Zou WY, Pu TL, Monai H, Murlidharan G, Rivera RMC, et al. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018;7: e40070.